survival in patients with malignant gliomas of the brain

نویسندگان

hossein safdari from the neurosurgical service, imam hossein hospital, shahid beheshti university, of medical sciences, school of medicine, tehran, islamic republic of iran.

چکیده

the present retrospective study was designed to analyze factors with prognostic values a) within, and b) significantly associated with, short-term (12months or less) and long-term (more than 24 months) survival times, i n 72 consecutive patients treated for malignant gliomas. among 41 (57%) short-term surviving patients, the absence of both aphasia and motor deficit (as initial presenting symptoms), postoperative radiation therapy alone or in combination with chemotherapy, and reoperation were associated with a relatively better survival prognosis. among 15 (20.8%) long-term surviving patients, postoperative radiation therapy and anaplastic, as histological type of astrocytoma, were marginally associated with improved survival time. the addition of conventional chemotherapy to postoperative radiation therapy failed to show a significant improvement in survival time in both survival groups. the long-term survival was significantly associated with the following factors: age (under 51 years), reoperation and the absence of lymphocyte infiltration. a satisfactory quality and duration of survival was achieved in a minority of patients with malignant gliomas. furthermore, a more appropriate postoperative antitumor therapy may increase the number of these patients, by avoiding fatal injuries to the normal brain tissues induced by postoperative antitumor therapies.

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

SURVIVAL IN PATIENTS WITH MALIGNANT GLIOMAS OF THE BRAIN

The present retrospective study was designed to analyze factors with prognostic values a) within, and b) significantly associated with, short-term (12months or less) and long-term (more than 24 months) survival times, i n 72 consecutive patients treated for malignant gliomas. Among 41 (57%) short-term surviving patients, the absence of both aphasia and motor deficit (as initial presenting ...

متن کامل

18F-FDG PET/CT usefulness vs Tc99m-Tetrofosmin in the assessment of malignant brain gliomas: Report of two cases

Gliomas account for almost 80% of primary malignant brain tumors in adults. Magnetic Resonance imaging (MRI) is still the gold standard for diagnosis of brain tumors and brain 99mTc-tetrofosmin Single Photon Emission Computed Tomography (99mTc-tetrofosmin-SPECT) has been established as a useful tool for their evaluation. Fluorine-18–2-fluoro-2-deoxy-d-glucose positron emi...

متن کامل

the study of aaag repeat polymorphism in promoter of errg gene and its association with the risk of breast cancer in isfahan region

چکیده: سرطان پستان دومین عامل مرگ مرتبط با سرطان در خانم ها است. از آنجا که سرطان پستان یک تومور وابسته به هورمون است، می تواند توسط وضعیت هورمون های استروئیدی شامل استروژن و پروژسترون تنظیم شود. استروژن نقش مهمی در توسعه و پیشرفت سرطان پستان ایفا می کند و تاثیر خود را روی بیان ژن های هدف از طریق گیرنده های استروژن اعمال می کند. اما گروه دیگری از گیرنده های هسته ای به نام گیرنده های مرتبط به ا...

15 صفحه اول

منابع من

با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید


عنوان ژورنال:
medical journal of islamic republic of iran

جلد ۲، شماره ۳، صفحات ۲۰۱-۲۰۶

کلمات کلیدی

میزبانی شده توسط پلتفرم ابری doprax.com

copyright © 2015-2023